Molecular Formula | C12H25N3O6 |
Molar Mass | 307.34 |
Storage Condition | -20℃ |
Physical and Chemical Properties | Bioactive Azido-PEG6-alcohol is a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC molecules. Azido-PEG6-alcohol is also a non-cleavable ADC linker containing 6 unit PEG, which can be used to synthesize antibody-coupled drugs (ADC). |
Downstream Products | O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL 17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 3.254 ml | 16.269 ml | 32.537 ml |
5 mM | 0.651 ml | 3.254 ml | 6.507 ml |
10 mM | 0.325 ml | 1.627 ml | 3.254 ml |
5 mM | 0.065 ml | 0.325 ml | 0.651 ml |
target
PEGs
Non-cleavable
in vitro study
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.